Clinical trials

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APGOT-OV14/ ENGOT-ov92/ TROY
  • Leading group Korea
  • Clinical Trial Study A phase 2, open-label, Multicenter, Randomized study of Trastuzumab Deruxtecan versus investigator’s choice chemotherapy in recurrent ovarian cancer that progressed on prior PARP inhibitor therapy
  • Planned number of patients 116/In preparation
  • Participating groups China, India, GCGS, EORTC (ENGOT)
APGOT-OV13/ DO-01
  • Leading group GEICO (ENGOT)
  • Clinical Trial Study A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer
  • Planned number of patients 52/In preparation
  • Participating groups Korea, GCGS, Japan, ANZGOG
APGOT-OV12/ GLORIOSA
  • Leading group GOG
  • Clinical Trial Study Randomized, multicenter, open-label, Phase 3 study of mirvetuximab soravtansine in combination with bevacizumab versus bevacizumab alone as maintenance therapy for patients with FRα-high recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancers who have not progressed after second-line platinum-based chemotherapy plus bevacizumab
  • Planned number of patients 520/Ongoing
  • Participating groups Korea, Australia, Japan
APGOT-OV11/ SOCCER-P
  • Leading group KGOG
  • Clinical Trial Study A randomized phase II study of secondary cytoreductive surgery in patients with relapsed ovarian cancer who have progressed on PARP inhibitor maintenance
  • Planned number of patients 124/Ongoing
  • Participating groups JGOG, GCGS
APGOT-OV10/ ROSELLA
  • Leading group GOG
  • Clinical Trial Study A Phase 3 Study of Relacorilant in Combination with Nab-Paclitaxel versus Nab-Paclitaxel Monotherapy in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube Cancer
  • Planned number of patients 360/Closed
  • Participating groups Korea, ANZGOG
APGOT-OV9/ Reframe-01
  • Leading group GINECO (ENGOT)
  • Clinical Trial Study REFRaME-O1: A Phase 2/3 Open-label Study Evaluating the Efficacy and Safety of Luveltamab Tazevibulin (STRO-002) versus Investigator’s Choice (IC) Chemotherapy in Women with Relapsed Platinum-resistant Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers)
  • Planned number of patients 600/Closed
  • Participating groups Korea, Australia, Singapore
APGOT-OV8/ ARTISTRY-7
  • Leading group GOG
  • Clinical Trial Study A Phase 3, Multicenter, Open-Label, Randomized Study of Nemvaleukin Alfa in Combination with Pembrolizumab Versus Investigator’s Choice Chemotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
  • Planned number of patients 450/Closed
  • Participating groups Korea, Australia
APGOT-OV7/ ENGOT-ov80/ DOVE
  • Leading group Korea
  • Clinical Trial Study A three-arm randomized phase II study of Dostarlimab alone or with Bevacizumab versus nonplatinum chemotherapy in recurrent gynecological clear cell carcinoma
  • Planned number of patients 198/Ongoing
  • Participating groups TGOG, HK, GOTIC, GCGS, ANZGOG, GTG-UK (ENGOT)
APGOT-OV5/ ENGOT-ov63/ NIRVANA-1
  • Leading group GINECO (ENGOT)
  • Clinical Trial Study A Randomized Study of Paclitaxel – Carboplatin followed by maintenance
    Niraparib compared to Paclitaxel – Carboplatin – Bevacizumab followed by maintenance Niraparib + Bevacizumab in Patients With Advanced Ovarian Cancer Following a Front-Line Complete Cytoreductive Surgery
  • Planned number of patients 390/Ongoing
  • Participating groups Korea, GOTIC
APGOT-OV4/ OPEB-01
  • Leading group Korea
  • Clinical Trial Study A single-arm phase II study of Olaparib maintenance with Pembrolizumab & Bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer
  • Planned number of patients 44/Closed
  • Participating groups GCGS
APGOT-OV3/ LARA
  • Leading group GCGS
  • Clinical Trial Study Phase II trial of Lenvatinib plus Pembrolizumab in Recurrent gynecological clear cell Adenocarcinomas
  • Planned number of patients 25/Closed
  • Participating groups Korea
APGOT-OV2/ MOCCA
  • Leading group GCGS
  • Clinical Trial Study A Multicentre Phase II Trial of Durvalumab Versus Physician's Choice Chemotherapy in Recurrent Ovarian Clear Cell Adenocarcinomas
  • Planned number of patients 46/Closed
  • Participating groups ANZGOG, KGOG
APGOT-OV1/ VIP
  • Leading group GCGS
  • Clinical Trial Study Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer
  • Planned number of patients 98/Closed
  • Participating groups ANZGOG, Korea